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File 170433546768.png - (593.20KB , 754x449 , thumb.png )
3312 No. 3312 hide watch quickreply [Reply] [Edit]
Hey everyone,

I just read this cool article (1) about mulberry fruit extracts and how they might slow down skin aging, thanks to their polyphenols. It's on ScienceChronicle.org and talks about how these extracts help fight glycation and boost antioxidant functions.

This got me thinking – what's the real deal with polyphenols and anti-glycation? I mean, are all polyphenols equally good at this, or do some work better than others? And does their structure make a difference in how well they stop those AGEs from forming, especially for skin health?

Also, is there any debate among scientists about how effective these polyphenols really are? I’m curious to know what both sides are saying.

Would love to hear your thoughts or any cool studies you might know about!

(1) https://www.sciencechronicle.org/news/mulberry-extracts-anti-aging-antiglycation-antioxidant-evaluations/

Post edited on 3rd Jan 2024, 6:34pm
>> No. 3313 [Edit]
I can't tell if this is an absurdly high-effort version of the "miracle berry" spam ads, or an actual discussion topic from someone with biochem experience.

Unless there's other biochemists lurking here I think you might have to break things down for us layman a bit more: I have some vague knowledge of polyphenols being good antioxidants, but beyond that what's the particular role between anti-glycation and skin health? Is there a particular reason you're interested in skin health (it seems like other factors like metabolic health or basically any other body part would be more substantive).
>> No. 3315 [Edit]
Might be a spam ad, generated by AI.
>> No. 3316 [Edit]
Why would I want to extend my life and misery though?
>> No. 3317 [Edit]
>>3315
You may actually be right, that "sciencechronicle.org" website seems a bit suspicious, it basically has a pagerank of 0, not having any inbound links from a reputable site. And the only links to that site that exist on the web are either from random spam domains, or from other chans/forums, which use the same copy-pasted text as OP.

The thing that confuses me is that the site itself is fairly "clean", it doesn't have any trackers besides google analytics, no ads from what I can see, minimal JS. So what's the point of this: high effort SEO farming? I'm guessing the article may be auto-generated, but it seems to have valid relevant citations which is not really something that LLMs are known for.

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2330 No. 2330 hide watch expand quickreply [Reply] [Edit]
Let's talk about web hosting and what that involves. I'm interested in diy solutions, especially for security. Cloudflare is now ubiquitous, but is it really necessary, or are there things web masters can do to protect their website themself?

I've seen some onion sites which have a password prompt to access. A simple pop-up that requests the user type in a given username and password. Is a simple solution like that good enough to defend against ddos attack?
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>> No. 2336 [Edit]
>>2332
>And a static IP
You can work around this with a dyndns type setup. And in practice your assigned ip usually remains fixed unless your reboot the modem so it shouldn't be too much of a hassle. Definitely not a commercial-grade solution though.
>> No. 2337 [Edit]
>>2335
>See linked paper
The solution proposed in this article requires the involvement of ISPs, at least to update routers. So is a purely software-based solution that would put the computing burden of authentication on users impossible because of the physical infrastructure of the internet?

Could the address of a website not be obfuscated in some way, and periodically changed, so that the only way to find it and send packets to it, would be for the client to run a program that solves a complicated math problem or something?
>> No. 2338 [Edit]
File savage-traceback-sigcomm00.pdf - (124.17KB )

2338
>>2337
> requires the involvement of ISPs, at least to update routers
Yeah hence why I mentioned it requires basically redesigning the architecture of the internet.
>So is a purely software-based solution
I think what you mean is whether there exists a solution that can be implemented on top of the existing routing architecture, involving only changes to the endpoints? If so, my intuition is that this is not possible because by design the way routing works on the Internet is that a client can send packets to an server without that server having prior knowledge that the client exists. And in fact, since a client can spoof the source IP the server fundamentally _can't_ be sure of the client's identity. (Note: good ISPs will have ingress IP checks and nullroute spoofed packets, but all it takes is one non-conforming ISP to allow for this).

You might be interested in the attached paper which shows that even solving a strictly simpler problem: reconstructing the path that a packet takes throughout the network (thereby preventing spoofed source IPs) is still very difficult. The authors use a very elegant packet tagging scheme and go to great efforts to maintain compatibility with the existing IP packet formats. But the fundamental limitation is that it requires a significant fraction of ISPs to adopt it, and given that packet routing is mostly done in hardware these days it will require huge costs to replace all this hardware as well. (More generally, you'll see this chicken and egg situation is the single biggest issue with bringing academic research in networking security into practice. They usually only work if there's mass adoption, but no one will be the first to adopt it due to costs).


>Could the address of a website not be obfuscated in some way, and periodically changed, so that the only way to find it and send packets to it, would be for the client to run a program that solves a complicated math problem or something?

Once you deobfuscate it on one client, you can share that deobfuscated address between all clients. The asymme
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>> No. 3307 [Edit]
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3307
Pro-tip, if you don't want to pay extra for a VPS that has an ipv4 address, you can use this to make your ipv6 only site accessible to those who only have an ipv4 address:

http://v4-frontend.netiter.com/

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2992 No. 2992 hide watch expand quickreply [Reply] [Edit]
Well, I want to wanna learn. Blows my mind reading some of these threads where it's like I'm reading another language. The whole thing is overwhelming, which only intrigues me more. How did you get started with coding/internet languages/programming. I don't even know what to call it, see? Where does one begin? I remember buying a C64 a few years ago with the goal of learning basic and creating a very simple game like the protagonist in RPO, but I gave up pretty fast and sold the god damn thing. Bought a Vic-20 too for some reason, but I still have that. Think I was just obsessing over old computers at the time. Had some experience with python in my physics class, but that didn't last long cuz I dropped that major the next semester lol.

Please, I at least want some kind've a general idea about what the fuck you guys are saying sometimes. It's so intimidating, but fascinating. Like I know another reality exists within my own, but I can't perceive or interact with it in any meaningful way. Where do I start?
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>> No. 3011 [Edit]
>>3010
>subtopics pertaining
You mean restoring vintage computers? There's a decent amount of people into retrocomputing (not on TC but elsewhere on the internet), and you don't even necessarily have to know anything about programming to do that. In fact having some soldering knowledge will probably be more useful since you'll probably need to replace bad capacitors and such. But I'm not sure what people do with them once they get it running.
>> No. 3012 [Edit]
>>3011
Good point haha, I guess the only real thing you can do is mess with software formats that aren't compatible with today's computers. I have a lot of old floppy discs I'd love to check out. Maybe even buy some vintage games and run them on their original hardware for that authenticity. I'm not too sure haha, but I know for sure it spikes my interest. What interested you and what subtopic do you thrive in?
>> No. 3013 [Edit]
>>3012
>what subtopic do you thrive in?
I wouldn't say I'm interested in a particular subfield more than any other, I find all of them interesting and will eagerly seek out opportunities to learn more about them.

>What interested you
I don't really remember. I think it's just that I spend a lot of time on the computer, so it was a motivation to know enough to be able to have unilateral control over my environment. And to be able to confidently mess around with things, you need to know how they work.
>> No. 3286 [Edit]
My issue with programming is that I am extremely stubborn and can't focus on things that I have no interest in. So, in python class for example, when they tell me to code something that figures out how to perform some sort of function based around division of numbers or whatever, I just lose interest. If the language were written in such a way that classes, objects, strings etc were called "swords", "spells", "dragons" etc I would be more mentally stimulated and pay attention...

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2447 No. 2447 hide watch expand quickreply [Reply] [Edit]
What do you think about the open source, UNIX-inspired Fuchsia(aside from it being developed by google). I am an ignoramus and windows user, but in spite of that, Fuchsia has(or will have) a few things that seriously appeal to me.

>Zircon is the core that powers Fuchsia. It is composed of a microkernel and a small set of userspace services, drivers, and libraries necessary for core system functions such as booting.
>Fuchsia’s filesystems live entirely within userspace. They are not linked nor loaded with the kernel; they are simply userspace processes that implement servers that can appear as filesystems. As a consequence, Fuchsia’s filesystems themselves can be changed with ease
>Due to the modular nature of Fuchsia’s architecture, it is straightforward to add filesystems to the system.
>Zircon is an object-based kernel. User mode code almost exclusively interacts with OS resources via object handles.
>In Fuchsia, almost everything is a component and it is the unit of executable software... Components can only use shared libraries that are included in the same package as the component... There is no concept of inter-package dependencies
>A given release of the Fuchsia platform typically supports multiple ABI revisions, which lets the platform run older applications
>This document proposes a mechanism for running unmodified Linux programs on Fuchsia... the Fuchsia system does not impose an opinion about the internal structure of components. In order to interoperate as a first-class citizen with the Fuchsia system, a component need only send and receive correctly formatted messages over the appropriate zx::channel objects... The programs are run in a userspace process whose system interface is compatible with the Linux ABI. Rather than using the Linux kernel to implement this interface, we will implement the interface in a Fuchsia userspace program

I like that it uses a microkernel, the filesystem implementation is so flexible, the kernel is object-based, and there's no possibility of dependency hell. As a windows user, I can't really understand
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>> No. 3265 [Edit]
File 169292653057.png - (158.36KB , 1650x1650 , 9f4784ca7072a5177bb2e8370700da79.png )
3265
Version 12
https://fuchsia.dev/whats-new/release-notes/f12
>> No. 3285 [Edit]
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3285
Version 14
https://fuchsia.dev/whats-new/release-notes/f14

A lot of work has been done on Starnix, the Linux comparability layer. Some risc-v stuff too.
>> No. 3321 [Edit]
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3321
https://9to5google.com/2024/01/15/google-is-no-longer-bringing-the-full-chrome-browser-to-fuchsia/

Yeah, people were right to doubt the longevity of this project. How sad. Looks like everybody is still going to be stuck with the same 3, shitty options. Windows with its updates and privacy concerns and ui fuckery, MacOs with its vendor lock-in, over-priced hardware and walled-garden, and Linux which is just shit.
>> No. 3365 [Edit]
In spite of the bad news, I'm still checking up on this. Version 16 has been released.
https://fuchsia.dev/whats-new/release-notes/f16

A bunch of additions and improvements to starnix
>Added support for /dev/uinput and route it appropriately to the Fuchsia input subsystem.
>Enabled RISC-V support in Starnix with basic tests running (Starnix with vDSO tests).
>Initial implementation of SELinux server in Starnix.
Also some connectivity improvements.

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2137 No. 2137 hide watch expand quickreply [Reply] [Edit]
Thread for general discussion of p2p networks and protocols.

Here's some uncharted territory: there's apparently some Japanese p2p projects. 新月 (掲示板) is a BBS, Perfect Dark and Share are file sharing services. Perfect dark also has a message board system. Does anybody use these? Are there others?
https://shingetsu.info/
https://w.atwiki.jp/botubotubotubotu/pages/28.html
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>> No. 3273 [Edit]
>>3272
>We're reinventing the hosts file?
I2P does, yes.

>I don't understand why crypto(currencies) are always intertwined into these things.
Normally I'd agree crypto involvement is superfluous, but for this use case it makes sense. Domains names are an intrinsically valuable thing, unlike a torrent's location on a DHT. More than one person is gonna want the same domain, and a first come first serve approach would enable squatters too much.
>> No. 3278 [Edit]
>>2800
Small addendum, don't use a pre-release version. It should say 'latest'.
>> No. 3280 [Edit]
>>2800
Another addendum, with the release of version 0.5, those peers wont work anymore. You should check a recently updated page in https://github.com/yggdrasil-network/public-peers

Also, you might have to look in C:\ProgramData\Yggdrasil and update the configuration file there too.
>> No. 3345 [Edit]
Installing Yggdrasil seems to have been made easier on Windows. I didn't need to manually add peers on a fresh install this time.

Post edited on 8th Feb 2024, 4:26pm

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3246 No. 3246 hide watch quickreply [Reply] [Edit]
https://twitter.com/alexkaplan0/status/1684044616528453633
This seems like a kind of big deal
>> No. 3247 [Edit]
I think you mean room-temp SUPERconductor, you wouldn't be posting on TC without room-temp semiconductors.

Replication attempts have been mixed, but theoretical simulation has shown there might be something to it, so it's not a complete hoax. Even if it does work, it'd probably take 5 years or so before the process gets ironed out, techniques refined, and it starts seeing practical application. Also >>3242
>> No. 3248 [Edit]
Maybe the most interesting read from a meta-perspective: https://hackmd.io/@lifthrasiir/lk-99-prehistory

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36 No. 36 hide watch expand quickreply [Reply] [Edit]
I thought the ponderings thread was getting a little computer-heavy, so I made this thread for general whinging about technology and the like. It sort of already exists in other threads, but that didn't stop people...
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>> No. 1627 [Edit]
>>1623
i run a separate machine for my file server because i found out i don't like sharing ram and bandwith with the outside world. i capped the server's bandwith at a bit below my total capacity so it can do it's thing and it never causes me any trouble.
>> No. 1639 [Edit]
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1639
I am trying to read a handful of ext4 formatted drives from windows. However, since I used some specific format parameters so I could save disk space, some of the linus fs readers don't work. This one called ext2fds actually allows you to mount drives right in windows but it only works with the one partition I formatted with default parameters. Another, called DiskInternals Linux Reader, does work but only lets you browse the file sytems in their standalone program. You have to "save" files you want to copy over to use them normally. Real round about way of doing things but oh well.

Post edited on 31st Jan 2018, 9:01pm
>> No. 3228 [Edit]
I never cared too much about the X vs Wayland holy war, but today I installed a recent Ubuntu, since I needed it for some software.
I just slapped Xubuntu desktop on top of a default server install, which gave me Gnome for some reason.
When connected via an old KVM it would only allow me to select 1024x768 as resolution, and apparently there is no way to override the mode in Wayland and the only solution proposed on the internet is to go back to X.
They've been touting it as the new, 100% production ready, absolutely superior software for what, 5 years now?
And it can't even do a simple thing like custom modelines.
What a load of shit.
And while I'm at it, the gnome display manager is shit too. If the user has passwordless login enabled I can't even select the desktop environment to start in X mode.
Solution according the internets? Well you can't do that either fuckhead, just have a password.
And if you happen to have a long MotD it hangs for a minute before logging you in, displaying parts of it.
Probably because it wants to show you the entire thing and give you time to read it, but there is no way to skip, and then when it gets to the last chunk, it just shows it for a millisecond and then logs you in.
What a fucking shitfest, especially considering these projects are heavily backed by the likes of red hat and other tech giants.
It's like modern software is purposefully built to be bad.

Although I have to admit that I kinda like the visual theme used in Ubuntu.
Looks a bit like late 2000s Mac OS, but damn, skeuomorphic designs in this day and age are such a breath of fresh air.
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>> No. 3229 [Edit]
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3229
>>3228
>these projects are heavily backed by the likes of red hat and other tech giants
Not really. I wouldn't call Red Hat a "tech giant". Yeah, they're owned by IBM, but that's a has-been company. I don't know how often Gnome(Wayland's real reason for existing) is used in the corporate world, but I'm certain it's not common-place. So even for Red Hat, it can't be that high-priority. FAANG couldn't care less about Wayland.

>It's like modern software is purposefully built to be bad.
Xorg isn't good compared to its common, proprietary equivalents. Tangentially related, but GTK also isn't good. There was no golden age of desktop Linux.

Post edited on 29th Jun 2023, 3:59pm

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3198 No. 3198 hide watch quickreply [Reply] [Edit]
can I make a mini PC with this and a phone screen?

Post edited on 27th Apr 2023, 2:47pm
>> No. 3199 [Edit]
>>3198
Why not just buy a pinephone or something.
>> No. 3200 [Edit]
Phone screens are a pain in the ass to work with, there's tiny HDMI monitors out there. Or Raspi cases with a screen built in.
>>3199
It's a better hand toaster than it is a PDA.
>> No. 3201 [Edit]
>>3200
At such a small size, touch screen would work better than just a simple monitor. I assume that's what OP actually means here, so you probably aren't wrong.

File 167700012565.png - (64.67KB , 850x353 , Cross-section-schematic-of-an-ICP-MS-adapted-from-.png )
3138 No. 3138 hide watch expand quickreply [Reply] [Edit]
Celebrating 25 Years of Inductively Coupled Plasma-Mass Spectrometry
Posted: September 26, 2008
2008 marked the 25th anniversary of inductively coupled plasma-mass spectrometry (ICP-MS). The marriage of ICP and MS resulted in an analytical technique capable of multielemental determinations. This capability opened up larger areas of the periodic table for environmental, forensic, biological, and material science analysis. Since its birth, ICP-MS has evolved rapidly and is at the forefront of elemental and trace metals analysis worldwide.
Background information

Over 25 years ago, mass spectrometry was rarely used for the routine determination of trace elements. There were several issues with the technique that made routine trace analysis impractical at the time. These included unsuitable ion sources, extensive sample preparation, and time-consuming analysis. Prior to ICP-MS, other techniques used to perform elemental analysis included atomic absorption spectroscopy (AAS) and inductively coupled plasma-optical emission spectroscopy (ICP-OES).

AAS uses the absorption of light by atoms to measure their concentrations. Initially, the sample is vaporized in a flame or graphite furnace. The elemental concentration of a sample can be determined as the atoms transition to a higher energy level through the absorption of light. The instrument is calibrated using standard solutions for the elements to be quantitated. However, AAS is subject to certain matrix effects that may require the use of modifiers. Use of the graphite furnace reduces the matrix effects because of the high temperature of the furnace.

ICP-OES is another technique used to determine trace elements in a sample. The ICP excites the atoms and ions in a sample to produce light of wavelengths that are characteristic of each of the elements in the sample. Even though the high temperature of the plasma for all practical purposes eliminates matrix effects, there are interferences caused by the overlapping of the spectral wavelengths of certain elements, which makes it difficult to distinguish these elements in a sample.

Therefore, researchers began the search for a new technique for the determination of trace elements that could address problems experienced by other techniques. Much of the R&D on ICP-MS was performed by researchers Rober
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>> No. 3142 [Edit]
Source: https://www.americanlaboratory.com/913-Technical-Articles/764-Celebrating-25-Years-of-Inductively-Coupled-Plasma-Mass-Spectrometry/

Do you have an interest in this field? Any particular reason for posting this article?
>> No. 3143 [Edit]
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3143
>>3142
I've become an ICP-MS otaku. It's a very profitable field to be an otaku in. Also, the wikipedia page doesn't mention the history of this technique at all. It's very new as far as scientific methods go, and very widespread across many different fields and industries.
>> No. 3188 [Edit]
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3188
Sample introduction really is the Achilles' Heel of ICP-MS. Our nebulizer was only producing large drops rather than a fine mist, resulting in the signal gradually dropping down to only 10% of what it once was.

I'm not 100% sure what it was, but my guess is that our calibration solutions were forming silver chloride particles (due to the presence of chloride) which eventually clogged or damaged the nebulizer. I didn't realize that we had accidentally ordered a Tin standard in 40% (!) hydrochloric acid, rather than dilute nitric and hydrofluoric acid. The procedure was calling for these solutions to only be re-made rarely, but often drawn from for dilutions, giving plenty of time for silver chloride particles to nucleate and grow. Given that we regularly rinse with dilute nitric, which should dissolve all the silver chloride, I think it's more likely permanent damage to the nebulizer rather than a simple clog. The new nebulizer ($1800 price tag! ouch!) brought the signal back to where it should be (and a clearly visible fine mist, without large drops, pic related).
>> No. 3189 [Edit]
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3189
Also, turns out our Argon dewar that fuels the plasma (flame) drops to low pressure at around 1/2 to 1/4 remaining capacity. We need about 7-8x atmospheric pressure of argon in there to fuel the plasma adequately. A bit disappointing since I wanted to test some samples, but wasn't able to get a resupply on short notice (we don't have enough room to keep a backup dewar to swap over when we run out.)

The ice formation on all the piping is due to minor leaks. When the gas inside the dewar (7+ times atmospheric pressure) leaks out, the expansion of the gas cools it down quite significantly. This makes the metal pipes very cold, which then freezes water vapor from the air into these ice crystals. You can see a similar process if you use a can of compressed air (computer duster).

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2008 No. 2008 hide watch expand quickreply [Reply] [Edit]
From the classical point of view, it is natural to assume that everything that happens in our world must have a reason. This reason may be hidden, unknown, but it must be; it is this consideration that underlies attempts to create a more detailed theory of the phenomena of the microcosm. But from the point of view of conventional, orthodox quantum mechanics, the theory of hidden parameters is impossible, if only because it does not have its own subject "behind the scenes" of quantum phenomena simply, according to quantum mechanics, there is nothing.
Is quantum indeterminism the absolute truth? I quote from Paul Dirac's book the Directions in Physics: "I do not rule out the possibility that Einstein's point of view may be correct in the end, because the current stage of development of quantum mechanics cannot be considered as final. There are many unsolved problems in this theory. Modern quantum mechanics is the greatest achievement, but it is unlikely to exist forever. It seems to me very likely that some day in the future there will be an improved quantum mechanics, which will contain a return to causality and which will justify the point of view of Einstein. But such a return to causality can only be possible at the cost of abandoning some other fundamental idea that we now accept unconditionally. If we are going to revive causality, we will have to pay for it, and now we can only guess what idea should be sacrificed."
Is this question open today in the scientific community, or does everyone believe that if Bell inequality has not been solved, then hidden parameters do not exist?
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>> No. 2940 [Edit]
Of note, the nobel prize in physics has been awarded for work on demonstrating violations of bells inequality in a wide range of circumstances. It's surprising that the last gap here was only closed in 2017. So at this point, assuming system-measurement independence, because we have observed violations of bells inequality in a robust set of circumstances we cannot have a local hidden variables theory. Or put another way, any theory of QM that is consistent with our observations must either:

* Reject the notion of system-measurement independence (superdeterminism)
* Reject locality (assume FTL communication of some form)
* Reject realism (the notion that particles have defined properties before measurement, i.e. that "god does not play dice" as Einstein supposedly said)

Most mainstream people like to preserve the notion of independence and locality so it's usually realism that gets chucked out (resulting in either copenhagen or many worlds)


[1] https://nautil.us/they-probed-quantum-entanglement-while-everyone-shrugged-241212/
[2] https://www.quantamagazine.org/pioneering-quantum-physicists-win-nobel-prize-in-physics-20221004/
>> No. 2941 [Edit]
>>2940
I find it interesting how much being a NEET screws with one's sense of time. When I heard the news about this I thought about when the Literature prize was going to be awarded, and saw October, I thought fuck that's months from now. Then just after, the prize comes in. We are in October after all.
>> No. 2942 [Edit]
>>2941
I've lost many many years like that.
>> No. 3129 [Edit]
https://news.yahoo.com/why-more-physicists-starting-think-045308127.html
Not sure how relevant this is, but posting it anyway. Maybe string theory will get left in the dust bin.

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418 No. 418 hide watch expand quickreply [Reply] [Edit] [Last 50 posts]
Let's turn this thread into a browser war!
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>> No. 3026 [Edit]
>>3025
Every chromium fork has the same problems. The obscenely, overly tall, non-adjustable tabs, designed for touch screens, and the god awful management of history and bookmarks. Some, like Edge, improve the latter two problems a little bit, but not substantially enough.

And then there's the whole "delete history older than 3 months" shit, which I've complained about many times. Forks also seem to guzzle up even more ram than vanilla chrome does.
>> No. 3098 [Edit]
>>3021
I just tried firefox recently and the experience is so god-awful, I had to make sure I hadn't accidentally gotten some adware laden version instead. On launch you've got sponsored websites on the homepage, below that "recommendations by pocket", and a dedicated pinned tab icon for "firefox view". And not to mention the lack of any separation between tabs. And perhaps most egregiously, you can't even do something basic like rebind keyboard shortcuts, or even install an extension from a folder. Firefox was supposed to be a browser for the people, but it seems more like a sellout to me.
>> No. 3099 [Edit]
>>3098
What do you use as a daily driver? If it's a Chromium fork, >>3026 is what I have to say about that. Adding something is a lot harder than removing it.
>> No. 3100 [Edit]
>>3098
There's always DILLO, anon.

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